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作者对皮下注射由双棕榈酰磷脂酰胆碱(DPPC)/双豆蔻酰磷脂酰甘油(DMPG)、DP-PC/双棕榈酰磷脂酰乙醇胺(DPPE)、DPPC/磷脂酰丝氨酸(PS)配制的、含牛血清白蛋白(BSA)、鼠单克隆抗体(McAb)GK1.5或21肽[来自于人类免疫缺陷症病毒(HIV)gp12O第二保守区的第254-274位氨基酸]的脂质体诱生抗体的能力进行了研究,同时也观察了口服含重组曼氏血吸虫28kDa谷胱甘肽-S-转移酶(Sm28GST)的上述脂质体诱生分泌性IgA(sIgA)、IgE和IgG的情况,并与明矾(Alum)和胞壁酰二肽(MDP)佐剂作对照.作者将雌性CD_1小鼠分成5组,分别于0、14天皮下免疫(1)抗原(Ag,5μg);(2)Alum/Ag(lmg/5μg);(3)MDP/Ag(50μg/
The authors dosed subcutaneously with a mixture of dipalmitoylphosphatidylcholine (DPPC) / dimyristoylphosphatidylglycerol (DMPG), DP-PC / dipalmitoylphosphatidylethanolamine (DPPE), DPPC / phosphatidylserine , Lipids containing bovine serum albumin (BSA), murine monoclonal antibody (McAb) GK1.5 or 21 peptide [amino acids 254-274 from the second conserved region of gp12O of human immunodeficiency virus (HIV)] The ability of in vivo induced antibodies was also investigated and the above liposomally induced secretory IgA (sIgA), IgE and IgG orally administered with the recombinant Schistosoma mansoni 28 kDa glutathione-S-transferase (Sm28GST) were also observed , And compared with Alum and muramyl dipeptide (MDP) adjuvant.The female CD 1 mice were divided into 5 groups and immunized subcutaneously (1) antigen (Ag, 5 μg) on days 0 and 14 respectively, ; (2) Alum / Ag (1 mg / 5 μg); (3) MDP / Ag