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目的 :探讨河南食管癌高发区青年食管癌患者 (≤ 4 0岁 )食管鳞癌组织中雌激素受体 (ER)和孕激素受体 (PR)的表达变化特征。方法 :采用免疫组织化学ABC法 ,检测 4 3例高发区青年食管癌患者手术切除标本ER和PR表达变化。结果 :高发区青年食管癌患者食管癌组织中雌激素受体阳性率为 4 7% ,孕激素受体的阳性率为7 %。ER、PR阳性率与组织分化程度、性别、淋巴结转移无关。结论 :食管癌高发区青年食管癌患者癌组织中有较高的ER表达 ,而PR阳性表达明显低于ER ,提示ER变化是青年食管癌患者频发的分子事件 ,进一步了解血清和组织雌、孕激素水平和ER的变化关系 ,将有助于加深对食管癌变机制的了解
Objective: To investigate the expression of estrogen receptor (ER) and progesterone receptor (PR) in esophageal squamous cell carcinoma (ESCC) patients with esophageal cancer (≤40 years old) in Henan esophageal cancer high incidence areas. Methods: Immunohistochemical ABC method was used to detect the expression of ER and PR in resected specimens of 43 young patients with esophageal cancer. Results: The positive rate of estrogen receptor in esophageal cancer tissues was 47% and the positive rate of progesterone receptor in esophageal cancer patients was 7%. The positive rates of ER and PR were not related to the degree of differentiation, gender and lymph node metastasis. Conclusion: The high expression of ER in esophageal cancer patients with esophageal cancer and the positive expression of PR is significantly lower than that of ER, suggesting that ER changes are frequent molecular events in young patients with esophageal cancer, to further understand the serum and tissue of female, Progesterone levels and changes in the relationship between ER, will help to deepen the understanding of esophageal cancer mechanisms