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目的 :探讨河南食管癌高发区食管癌组织中COX 2表达变化与食管癌细胞分化程度及淋巴结转移的关系。方法 :免疫组化ABC方法检测 31例食管鳞癌组织中COX 2的表达 ,以活检正常食管粘膜 10例为对照。结果 :COX 2免疫阳性反应主要定位于食管癌细胞的细胞质 ,正常对照组无COX 2表达。 31例食管癌组织中有 16例 (5 1.6 % )表达COX 2 ;食管癌组织分化的恶性程度与COX 2免疫反应的强度呈负相关 (r =- 0 .5 6 4 ;P =0 .0 0 1) ;伴淋巴结转移者 6 1.9%COX 2阳性 (13/2 1) ,但统计分析未发现COX 2的免疫反应程度与有无淋巴结转移间存在相关性 (K SZ =0 .830 ;P =0 .4 96 )。结论 :COX 2过度表达可能与食管癌细胞分化程度有关 ,可能成为食管癌防治 ,特别是高分化食管癌治疗的新靶点。
Objective: To investigate the relationship between the changes of COX-2 expression and the degree of esophageal carcinoma cell differentiation and lymph node metastasis in esophageal cancer of Henan province. Methods: Immunohistochemical ABC method was used to detect the expression of COX - 2 in 31 cases of esophageal squamous cell carcinoma and 10 cases of normal esophageal mucosa biopsy were used as controls. Results: The COX-2 immunoreactivity mainly localized in the cytoplasm of esophageal cancer cells, but no expression of COX-2 was found in the normal control group. COX2 was expressed in 16 of 31 cases (51.6%) of esophageal cancer tissues; the malignancy of esophageal cancer tissues was negatively correlated with the intensity of COX2 immunoreactivity (r = - 0.546; P = 0.0 0 1), 6 1.9% COX 2 positive (13/2 1) with lymph node metastasis, but there was no correlation between COX 2 immunoreactivity and lymph node metastasis (K SZ = 0.830; P = 0 .4 96). Conclusion: Overexpression of COX 2 may be related to the degree of differentiation of esophageal cancer cells and may be a new target for esophageal cancer prevention and treatment, especially for well-differentiated esophageal cancer.