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孕激素和睾酮合用可通过抑制垂体促性腺激素而控制男性生育力。单用睾酮虽能抑制精子生成并保持雄性激素的作用,但对睾丸功能的抑制和刺激作用之间的阀值很狭。为了寻找一个理想的男性避孕药,作者试用了19-去甲睾酮。 5名21～25岁健康自愿者,头3周每周肌注19-去甲睾酮的已氧基苯丙酸酯100mg,以后10周每周200mg。记录用药前、后睾丸和前列腺大小变化。用药期间定期取血作多项生化及内分泌激素测定。由世界卫生组织提供药盒,用高性能液相色谱分离睾酮及
Combination of progesterone and testosterone can control male fertility by inhibiting pituitary gonadotropin. Although testosterone alone can inhibit sperm production and maintain the role of androgen, but the threshold between inhibition and stimulation of testicular function is very narrow. In an attempt to find an ideal male contraceptive, the authors tried 19-nortestosterone. 5 healthy volunteers aged 21 to 25 years, the first three weeks of intramuscular injection of 19-nortestosterone phenoxy propionate 100mg, 10 weeks after the week 200mg. Record medication before and after testis and prostate size changes. Regular blood taken during treatment for a number of biochemical and endocrine hormones. Kit provided by the World Health Organization, high performance liquid chromatography for the separation of testosterone and