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目的 :探讨成人病毒性肝炎患者中柯萨奇病毒B组 (CoxsackievirusB ,CVB)散发性感染状况。方法 :用ELISA法测定病毒性肝炎患者血清中抗CVB -IgM抗体 ,同时应用荧光定量PCR方法测定HBVDNA及HCVRNA含量。结果 :4 5 7例病毒性肝炎患者中抗CVB -IgM阳性 13例 ,其中CVB单独感染者 1例。CVB感染组与阴性对照组在临床表现、肝功能试验、HBVDNA含量等方面相比无明显差异。结论 :病毒性肝炎患者中CVB感染率为 2 .84 % ,其肝炎病原学意义有待进一步研究
Objective: To investigate the sporadic infection of Coxsackievirus B (CVB) in adult patients with viral hepatitis. Methods: The anti-CVB-IgM antibody in the serum of patients with viral hepatitis was detected by ELISA, and the contents of HBVDNA and HCVRNA were determined by fluorescence quantitative PCR. Results: Of the 477 viral hepatitis patients, 13 were positive for anti-CVB-IgM, of which 1 was CVB-infected. CVB infection group and negative control group in clinical manifestations, liver function tests, HBVDNA content compared to no significant difference. Conclusion: The CVB infection rate in patients with viral hepatitis is 2.84%. The etiological significance of hepatitis remains to be further studied