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星状细胞(HSC)的激活是肝纤维化发生、发展的关键步骤。HSC的激活是通过各种细胞因子(CK)经旁分泌或自分泌途径作用的结果,并且活化HSC的CK受体表达增加。随着对CK研究的逐渐深入,针对CK的治疗有望成为抗肝纤维化的一种重要手段。现就与HSC相关的CK综述如下:
Activation of stellate cells (HSC) is a key step in the development of hepatic fibrosis. Activation of HSCs is the result of paracrine or autocrine pathways through various cytokines (CKs), and increased CK receptor expression of activated HSCs. With the gradual deepening of CK research, the treatment of CK is expected to become an important means of anti-liver fibrosis. The following is a summary of CK related to HSC: