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作者观察了3种钙通道阻断剂(维拉帕米、硝苯啶及尼群地平)对小鼠和人体免疫细胞功能的影响。在离体条件下,3种药浓度依赖地抑制人体外周血T、B淋巴细胞的增殖。小鼠ig给药,剂量为15 mg/kg qd×8 d时,3种药均显著抑制小鼠足跖迟发型超敏反应;剂量为15 mg/kg、45 mg/kg qd×7 d时,维扭帕米和尼群地平剂量依赖地降低血清溶血素水平,但硝苯啶在15 mg/kg 水平时,却显著增加溶血素水平;3种药物还有明显的抑制小鼠碳粒廓清的作用。
The authors looked at the effects of three calcium channel blockers (verapamil, nifedipine and nitrendipine) on immune cell function in mice and humans. Under ex vivo conditions, the three drugs inhibited the proliferation of T and B lymphocytes in human peripheral blood in a concentration-dependent manner. The mice were given ig administration for 15 days at a dose of 15 mg / kg qd for 8 days. All the three drugs significantly inhibited the delayed type hypersensitivity of the plantar. At the dose of 15 mg / kg and 45 mg / kg qd × 7 d , Dimetrodipramine and nitrendipine dose-dependently lowered serum hemolysin level, but nifedipine significantly increased the hemolysin level at 15 mg / kg level. The three drugs also significantly inhibited the clearance of carbon clearance in mice Role.