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目的：了解内皮素（ＥＴ）与一氧化氮（ＮＯ）在慢性肾衰患者中的变化。方法：按肾功能分期，将２９例慢性肾衰患者分为肾功能不全代偿期组、氮质血症期组、尿毒症期组，分别用放射免疫分析法和铬还原法测定其血浆ＥＴ和血清ＮＯ。结果：伴肾功能减退者血浆ＥＴ水平明显升高，ＮＯ水平并不下降，且在尿毒症组异常升高；ＥＴ水平与肾功能损害程度及肾性高血压严重度呈正相关，而ＮＯ则无相关性；血透后ＥＴ值进一步升高，而ＮＯ则明显下降。结论：认为ＥＴ和ＮＯ水平的异常可能与肾功能损害有关，可作为反映肾功能不全者病情严重性的一个指标
Objective: To understand the changes of endothelin (ET) and nitric oxide (NO) in patients with chronic renal failure. Methods: According to the stage of renal function, 29 patients with chronic renal failure were divided into compensatory renal insufficiency group, azotemia group and uremia group. The plasma ET And serum NO. Results: The level of plasma ET in patients with renal dysfunction was significantly increased, the level of NO did not decrease, and the level of ET in patients with uremia was abnormally elevated. The level of ET was positively correlated with the degree of renal dysfunction and the severity of renal hypertension. Correlation; hemodialysis ET value further increased, while NO decreased significantly. CONCLUSIONS: It is believed that the abnormalities of ET and NO levels may be related to renal dysfunction and may be used as an indicator of the severity of renal insufficiency