乙双吗啉诱发人患急性粒细胞白血病M_3型一例

来源 :佳木斯医学院学报 | 被引量 : 0次 | 上传用户:zdllyd2009
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患者男,37岁,因头晕、乏力,活动后心悸、气短、低热约1个月。近1周内鼻衄血、齿龈出血,皮肤出现瘀点瘀斑。于12—03—26来我院血液科入院治疗。既往史:该患者自幼患牛皮癣,曾常年服用乙双吗啡,查体:体温37.8℃,脉博86次/分,血压14/7kPa。患者意识清楚,口腔粘膜可见血泡,贫血外观,颌下淋巴结肿大,直径约0.5Cm,活动良好,有触痛,胸骨压痛,巩膜无黄染,右眼巩膜可见片状出血,结膜苍白,鼻腔有血迹,咽部充血,前胸部皮肤有出血点,双上肢及左内踝处有瘀斑。血常规:白细胞25.2×10~/L。血红蛋白86.5g/L,红细胞2.25×10~(12)/L ,血小板2×10~/L,,出血时间5分以上,凝血时间1.5分。白细胞分类:原粒%,早幼粒83%,分叶5%,淋巴3%。骨髓象:原始粒细胞10%,早幼粒细胞85%,分叶3%,淋巴2%,增生极度活跃,全片以原始粒细胞及早幼粒细胞增生为主。约占5%,细胞形态不规则,胞浆有伪足,淡蓝色,核圆或椭圆,核 Male patient, 37 years old, dizziness, fatigue, palpitations after activity, shortness of breath, fever for about 1 month. Nearly 1 weeks nosebleed, bleeding gums, petechiae petechiae appear on the skin. In 12-03-26 to our hospital hematology admission treatment. Past history: The patient with psoriasis since childhood, had taken B double morphine, perennial examination: body temperature 37.8 ℃, Pulse Bo 86 / min, blood pressure 14 / 7kPa. Patients with a clear sense of the oral mucosa visible blood bubble, anemia appearance, submandibular lymph nodes, diameter of about 0.5Cm, good activity, tenderness, tenderness, sternal sclera no yellow dye, the right eye sclera visible flaky bleeding, pale conjunctiva, Nasal blood, throat congestion, bleeding in the front chest skin, both upper extremities and left medial malleolus at ecchymosis. Blood: WBC 25.2 × 10 ~ / L. Hemoglobin 86.5g / L, red blood cells 2.25 × 10-12 / L, platelets 2 × 10 ~ / L, bleeding time of 5 points or more, clotting time of 1.5 minutes. White blood cell classification:% of the original particles, promyelotic 83%, 5% of leaves, lymph 3%. Bone marrow: 10% of the original granulocyte, promyelocytic 85%, lobectomy 3%, lymph 2%, hyperplasia extremely active, the whole piece of primary granulocytes and promyelocytic hyperplasia based. About 5%, irregular cell morphology, pseudopodia cytoplasm, light blue, nuclear or oval, nuclear
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