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目的 观察比索洛尔对急性心肌梗塞 (AMI)心率变异性 (HRV)的影响。方法 将 50例AMI患者随机分成观察组和对照组各 2 5例 ,两组均采用相同的常规和急救用药 ,观察组加服比索洛尔 2 .5～ 5mg ,1日 1次。用 2 4h动态心电图 (含有HRV软件 ) ,进行心率 (HR)、相邻R -R间期 >50ms的百分比 (PNN50 )、变异系数 (CV)、低频带 (LF)、高频带 (HF)、低频 /高频 (LF/HF)的统计学分析。结果 观察组和对照组间HRV的HR、PNN 50、HF、LF/HF有显著性差异 (P <0 .0 5) ,CV、LF有极显著性差异 (P <0 .0 1) 。结论 HRV能被有关药物调整 ,可作为心脏性猝死的独立观察指标。
Objective To observe the effect of bisoprolol on heart rate variability (HRV) in acute myocardial infarction (AMI). Methods Fifty patients with AMI were randomly divided into observation group and control group, 25 cases in each group. The two groups were given the same routine and first aid medication. The observation group received 2.5 ~ 5 mg bisoprolol once a day. Heart rate (HR), percentages of adjacent R-R intervals> 50 ms (PNN50), coefficient of variation (CV), low frequency band (LF), high frequency band (HF) were measured with 24 h Holter electrocardiogram (HRV software included) , Low frequency / high frequency (LF / HF) statistical analysis. Results There were significant differences in HR, PNN 50, HF and LF / HF between the observation group and the control group (P <0.05), CV and LF (P <0.01). Conclusion HRV can be adjusted by relevant drugs and can be used as an independent observation of sudden cardiac death.