Arrestin-mediated signaling:Is there a controversy?

• 作 者: Vsevolod V Gurevich Eugenia V
• 机 构: DepartmentofPharmacology
• 出 处: 世界生物化学杂志:英文版(电子版)
• 发表日期: 2018年3期
• 关键词: G protein-coupled receptors ARRESTIN G protein SIGNALING Extracellular SIGNAL-RE
• 基金项目: National Institutes of Health RO1 grants,No.EY011500,National Institutes of Health R35 grants,No.GM122491,Cornelius Vanderbilt Endowed Chair(Vanderbilt University),No.NS065868(to Gurevich VV)and No.DA

The activation of the mitogen-activated protein(MAP)kinases extracellular signal-regulated kinase(ERK)1/2 was traditionally used as a readout of signaling of G protein-coupled receptors(GPCRs)via arrestins,as opposed to conventional GPCR signaling via G p