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探讨β内啡肽在新生儿硬肿症休克中的临床意义。应用放射免疫法测定１１例新生儿硬肿症休克患儿血浆β内啡肽含量。结果：新生儿硬肿症休克患儿血浆β内啡肽平均为１２０．４６±３．２９ｎｇ／Ｌ；显著高于对照组（２６．８０±１．５５ｎｇ／Ｌ）；死亡组与存活组、肺出血组与未出血组、产热状态良好与衰竭、血气ｐＨ值≤７．０与＞７．０组也见到相同的结果，而休克程度与心率快慢未见β内啡肽差异；酸血症剌激了β内啡肽的释放，其水平与心率呈负相关。说明β内啡肽可能介导新生儿硬肿症休克时的肺出血和产热状态。提示新生儿硬肿症休克时β内啡肽的释放加重了休克状态，并影响预后
To investigate the clinical significance of β-endorphin in neonatal scleredema. Radioimmunoassay was used to determine the plasma level of β-endorphin in 11 neonates with scleredema. Results: The average level of β-endorphin in children with neonatal scleredema was 120.46 ± 3.29ng / L, significantly higher than that in the control group (26.80 ± 1.55ng / L). The mortality and survivors, Pulmonary hemorrhage group and non-hemorrhage group, with good heat production and failure, blood gas pH ≤7.0 and> 7.0 group also see the same result, and the degree of shock and heart rate no difference in β endorphin; acid Hyperlipidemia stimulates the release of beta-endorphin, which is inversely correlated with heart rate. This suggests that β-endorphin may mediate pulmonary hemorrhage and thermogenesis in neonates with scleredema. Prompted neonatal pediatric sequelae release of beta endorphin aggravates the state of shock and affect the prognosis