【摘 要】
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Since the first HIV vaccine trial in 1986 a variety of vaccination strategies have been developed and tested for immunogenicity in clinical phase Ⅰ safety tria
【机 构】
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Department of Molecular and Medical Virology, Ruhr-University Bochum, Bochum 44801, Germany
论文部分内容阅读
Since the first HIV vaccine trial in 1986 a variety of vaccination strategies have been developed and tested for immunogenicity in clinical phase Ⅰ safety trials.Nevertheless,only six vaccines have been approved for phase Ⅱb/Ⅲ efficacy trials with only one,the Thai RV144 trial,showing modest efficacy in reducing the infection rate (reviewed in Esparza J,2013).A major obstacle in HIV vaccine development is the absence of clear correlates of protection,although the Thai trial revealed some correlation of non-neutralizing antibodies specific for the V1/V2 region of the envelope (env) protein and a reduced rate of infection (Haynes B F,et al.,2012).
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