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特异性细胞毒Ｔ淋巴细胞（ＣＴＬ）反应是人体清除ＨＢＶ的主要机制，与临床结局密切相关，了解病毒变异对ＣＴＬ反应的影响尤为重要。 １．ＣＴＬ表位区内的变异：ＣＴＬ通过识别ＨＢＶ抗原特异性表位而清除病毒，ＨＢＶ编码的蛋白产物上都有这种表位。表位区内的变异可能引起
Specific cytotoxic T lymphocyte (CTL) response is the main mechanism of human clearance of HBV, and clinical outcomes are closely related to understand the impact of virus mutation CTL response is particularly important. 1. Variants within the CTL epitope region: CTLs clear the virus by recognizing HBV antigen-specific epitopes that are present on HBV-encoded protein products. Epitope region variation may cause