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目的评估氟比洛芬酯复合丙泊酚与芬太尼用于人工流产术中及术后的镇痛效果。方法 ASAⅠ～Ⅱ级行无痛人流术的孕妇80例,随机分为A、B2组,每组40例,A组预先给予氟比洛芬酯,B组给予安慰剂(脂肪乳),2组均用丙泊酚复合芬太尼静脉麻醉。观察2组麻醉诱导前、意识消失时、扩宫结束时、苏醒时的HR、MAP、SpO2,记录丙泊酚用量、手术时间、苏醒时间、不良反应及术中麻醉效果,并应用VAS评分评估2组患者清醒后5、15和30min时的疼痛程度。结果与麻醉诱导前相比,2组在意识消失时、扩宫结束时HR、MAP下降(P均<0.05),且A组MAP波动幅度明显低于B组(P均<0.05);2组各时间点SpO2差异无统计学意义(P均>0.05)。A组术中镇痛达优率稍高于B组,但差异无统计学意义。丙泊酚用量A组少于B组(P<0.05);患者苏醒后15、30min时,A组VAS评分均明显低于B组(P<0.05,P<0.01);2组手术时间、苏醒时间差异无统计学意义。结论氟比洛芬酯复合丙泊酚与芬太尼可以安全有效地用于人工流产术的术中、术后镇痛。
Objective To evaluate the analgesic effects of flurbiprofen ester, propofol and fentanyl, during and after induced abortion. Methods Eighty pregnant women with ASA Ⅰ ~ Ⅱ painless abortion were randomly divided into group A and group B (n = 40). Group A received flurbiprofen axetil, group B received placebo (fat emulsion), group 2 Both with propofol fentanyl intravenous anesthesia. Before anesthesia induction, disappearance of consciousness, at the end of dilation, resumption of HR, MAP, SpO2, recorded propofol dosage, operation time, recovery time, adverse reactions and intraoperative anesthesia, and assessed by VAS score The degree of pain at 5, 15 and 30 min after awake in both groups. Results Compared with pre-anesthesia induction, HR and MAP decreased (P <0.05), and amplitude of MAP in group A was significantly lower than those in group B (P <0.05) There was no significant difference in SpO2 between time points (P> 0.05). The excellent rate of intraoperative analgesia in group A was slightly higher than that in group B, but the difference was not statistically significant. The dosage of propofol in group A was less than that in group B (P <0.05). The VAS scores in group A were significantly lower than those in group B at 15 and 30 minutes after awake (P <0.05, P <0.01) Time difference was not statistically significant. Conclusion The combination of flurbiprofen ester and propofol with fentanyl can be used safely and effectively in the intraoperative and postoperative analgesia of induced abortion.