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目的了解辽宁省急性弛缓性麻痹(AFP)病例中非脊髓灰质炎肠道病毒(NPEV)感染的情况。方法用逆转录-聚合酶链反应(RT-PCR)对NPEV进行鉴定,并对NPEV感染病例进行流行病学分析。结果辽宁省1990～2005年AFP病例中共有98例NPEV感染病例,NPEV分离率为7.8%。其中67.3%的病例为4岁以下儿童;59.2%的病例出现在6～8月;主要临床表现有发热(56.2%)、肌肉疼痛(29.6%)、腹泻(12.2%);58.2%的NPEV感染病例被诊断为格林-巴利综合征(GBS)。结论用RT-PCR方法鉴定NPEV快速、简单、经济、特异性强;NPEV可能是GBS的重要病因之一。
Objective To understand the non-polio enterovirus (NPEV) infection in acute flaccid paralysis (AFP) cases in Liaoning Province. Methods The NPEV was identified by reverse transcription polymerase chain reaction (RT-PCR), and the epidemiological analysis of NPEV infection was performed. Results A total of 98 cases of NPEV infection were found in AFP cases in Liaoning Province during 1990-2005. The NPEV isolation rate was 7.8%. Among them, 67.3% of cases were children under 4 years old; 59.2% of cases were seen from June to August; the main clinical manifestations were fever (56.2%), muscle pain (29.6%), diarrhea (12.2%) and 58.2% NPEV infection The case was diagnosed as Guillain-Barre syndrome (GBS). Conclusion The identification of NPEV by RT-PCR is rapid, simple, economical and specific. NPEV may be one of the important causes of GBS.