论文部分内容阅读
RNA干扰(RNA interference,RNAi)是一种生物进化过程中出现的高度保守现象,表现为转录或转录后的基因沉默,是近年研究基因功能的新方法。宫颈癌的发生是多基因参与并经多阶段演进而形成的疾病,RNAi现象的发现为宫颈癌的基因治疗提供了一种新的思路。通过RNAi技术可抑制宫颈癌致癌基因的表达,阻断细胞凋亡与分裂,增强宫颈癌传统化疗药物的敏感性,抑制肿瘤的浸润与转移,RNAi可能成为宫颈癌基因治疗的新策略。介绍RNAi的分子机制、特性以及RNAi技术在宫颈癌基因治疗领域的研究进展。
RNA interference (RNAi) is a highly conserved phenomenon that occurs in the process of biological evolution. It appears as a gene silencing after transcription or transcription. It is a new method to study gene function in recent years. The occurrence of cervical cancer is a multi-gene involved in multi-stage evolution and the formation of the disease, the discovery of RNAi for cervical cancer gene therapy provides a new way of thinking. RNAi can inhibit cervical cancer oncogene expression, block apoptosis and division, enhance the sensitivity of traditional chemotherapy drugs and inhibit tumor invasion and metastasis, RNAi may become a new strategy for gene therapy of cervical cancer. The molecular mechanism and characteristics of RNAi and the progress of RNAi technology in the field of cervical cancer gene therapy are introduced.