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目的:观察儿童回春颗粒联合喜炎平雾化吸入治疗小儿上呼吸道感染的临床疗效,及对患儿血清炎症因子和免疫功能的影响。方法:将本院214例上呼吸道感染患儿随机分为对照组和观察组,每组107例。对照组给予喜炎平雾化吸入,观察组在此基础上加用儿童回春颗粒口服。观察2组治疗前后炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、T细胞亚群(CD4、CD8、CD4/CD8)的变化,比较2组症状(发热、咳嗽、流涕)改善时间,评估治疗效果。结果:治疗后,2组TNF-α、IL-6水平均较治疗前降低(P<0.05);观察组的TNF-α、IL-6水平均低于对照组(P<0.05)。治疗后,2组CD4水平及CD4/CD8均较治疗前上升(P<0.05),CD8水平均较治疗前下降(P<0.05);观察组的CD4水平及CD4/CD8均高于对照组(P<0.05),CD8水平低于对照组(P<0.05)。观察组发热、咳嗽及流涕消失时间均短于对照组(P<0.01)。观察组治疗总有效率92.5%,高于对照组的80.4%(P<0.05)。结论:儿童回春颗粒联合喜炎平雾化吸入可有效控制上呼吸道感染患儿的炎症反应,改善免疫功能,治疗效果满意。
Objective: To observe the clinical curative effect of children’s rejuvenation granules combined with Xiyanping atomization inhalation on infantile upper respiratory tract infection, as well as the influence on serum inflammatory factor and immune function in children. Methods: 214 cases of upper respiratory tract infection in our hospital were randomly divided into control group and observation group, 107 cases in each group. The control group was given Xiyanping aerosol inhalation, the observation group on the basis of this supplement with children rejuvenation granules oral. The changes of inflammatory cytokines TNF-α, IL-6 and T cell subsets (CD4, CD8, CD4 / CD8) in two groups before and after treatment were observed. Symptoms (fever, cough, runny nose) to improve the time to assess the treatment effect. Results: After treatment, the levels of TNF-α and IL-6 in both groups were lower than those before treatment (P <0.05). The levels of TNF-α and IL-6 in the observation group were lower than those in the control group (P <0.05). After treatment, CD4 level and CD4 / CD8 in both groups were significantly higher than those before treatment (P <0.05) and CD8 levels were lower than those before treatment (P <0.05); CD4 level and CD4 / CD8 in observation group were higher than those in control group P <0.05), CD8 level was lower than that of the control group (P <0.05). The observation group fever, cough and runny nose disappear shorter than the control group (P <0.01). The observation group, the total effective rate was 92.5%, higher than 80.4% of the control group (P <0.05). Conclusion: The combination of children Huichun granule and Xiyanping atomization inhalation can effectively control the inflammatory reaction of children with upper respiratory tract infection and improve the immune function, and the treatment effect is satisfactory.