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目的:调查临床常用中药注射剂治疗心脑血管疾病系统评价/Meta分析的现状。方法:检索中国知网(CNKI,1979~2015年)和Pub Med(1990~2015年)文献数据库,筛选符合纳入标准的中药注射剂治疗心脑血管疾病的系统评价/Meta分析,提取有关信息,应用Microsoft Office 2010中Excel软件分析,并用AMSTAR和PRISMA量表对其方法学和发表质量进行评价。结果:纳入中药注射剂治疗心脑血管疾病类系统评价/Meta分析224篇,其中中文215篇,英文9篇,发表数量整体呈增长的趋势。出版刊物涉及93种期刊,其中篇数最多的是《中国中医急症》24篇(11.2%)。涉及中药注射剂30余品种,被评价次数最多的为参麦注射液17次(7.6%);用于治疗心血管疾病和脑血管疾病的临床评价数量相当。方法学质量、发表质量均以中等水平居多。结论:系统评价/Meta分析手段已得到较好的应用,为中药注射剂治疗心脑血管疾病临床循证决策提供了依据,但对中药注射剂的安全性问题鲜少涉及。因此,在今后的临床研究中,不仅需要进一步提高系统评价、临床试验水平,而且对中药注射剂治疗心脑血管疾病的有效性与安全性并重。
Objective: To investigate the status quo of systematic reviews / meta-analysis of commonly used traditional Chinese medicine injections in the treatment of cardiovascular and cerebrovascular diseases. METHODS: The literature databases of CNKI (CNKI, 1979-2015) and Pub Med (1990-2015) were searched. Systematic reviews / meta-analyzes of TCM injections that met the inclusion criteria were screened, and relevant information was extracted Excel software analysis in Microsoft Office 2010 and its methodology and publication quality using the AMSTAR and PRISMA scales. Results: A total of 224 systematic reviews / meta-analyzes of Chinese medicine injection for cardiovascular and cerebrovascular diseases were included, of which 215 were in Chinese and 9 were in English. The published numbers showed an overall trend of increase. The publications cover 93 journals, of which 24 are the largest in China (11.2%). More than 30 varieties of traditional Chinese medicine injections were involved, and the most frequently evaluated patients were Shenmai injection 17 times (7.6%). The clinical evaluations for treating cardiovascular diseases and cerebrovascular diseases were quite similar. Methodological quality, published quality are mostly middle level. Conclusion: The systematic reviews / meta-analyzes have been applied well and provided a basis for clinical evidence-based decision-making of Chinese medicine injection for the treatment of cardiovascular and cerebrovascular diseases. However, the safety of traditional Chinese medicine injections is rarely involved. Therefore, in the future clinical research, not only need to further improve the system evaluation, clinical trial level, but also the efficacy and safety of TCM injection for the treatment of cardiovascular and cerebrovascular diseases.