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目的:分析清华大学附属北京市垂杨柳医院铜绿假单胞菌(PA)耐药率与抗菌药物用药频度(DDDs)的相关性,为临床合理使用抗菌药物提供依据。方法:回顾性调查我院2010~2015年分离出的2 963株PA的耐药率以及同期常用抗革兰阴性菌抗菌药物的DDDs,对PA耐药率与抗菌药物DDDs进行Pearson相关性分析。结果:我院PA对哌拉西林/他唑巴坦、亚胺培南/西司他丁、莫西沙星的耐药率与其DDDs呈显著正相关(P<0.05),多重耐药铜绿假单胞菌(MDR-PA)检出率与亚胺培南/西司他丁的DDDs呈显著正相关(r=0.903,P=0.014)。结论:我院PA耐药率及MDR-PA检出率与某些抗菌药物的使用量存在一定的相关性,可能与耐药机制有关,其原因有待进一步研究。
OBJECTIVE: To analyze the correlation between the rate of drug resistance of Pseudomonas aeruginosa (PA) and the frequency of antimicrobial drugs (DDDs) in Chuihyangliu Hospital affiliated to Tsinghua University, so as to provide basis for the rational use of antimicrobial agents. Methods: The drug resistance rates of 2 963 PA isolates isolated from our hospital from 2010 to 2015 and DDDs of commonly used anti-gram-negative antibacterials in the same period were retrospectively analyzed. Pearson correlation analysis was conducted between PA drug resistance rate and antimicrobial DDDs. Results: The resistance rates of drug to piperacillin / tazobactam, imipenem / cilastatin, and moxifloxacin in our hospital were significantly and positively correlated with DDDs (P <0.05), and multidrug-resistant The detection rate of MDR-PA was positively correlated with DDDs of imipenem / cilastatin (r = 0.903, P = 0.014). Conclusion: The rate of MDR-PA and the detection rate of MDR-PA in our hospital are related to the usage of certain antimicrobial drugs, which may be related to the mechanism of drug resistance. The reason for further study is needed.