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目的:观察伊曲康唑与萘替芬酮康唑乳膏联用治疗复发性真菌性外耳道炎的疗效及安全性。方法:复发性真菌性外耳道炎患者48例随机分为两组。对照组24例给予萘替芬酮康唑乳膏外用,qd,连续2周。观察组24例在对照组基础上,加用伊曲康唑胶囊200 mg,po,qd,连续2周。比较两组近期及远期疗效,并评价安全性。结果:用药两周后,观察组总有效率为100.0%,明显优于对照组的83.3%(P<0.05)。治疗结束后6个月随访,观察组无1例复发,对照组复发率为20.0%;观察组复发率明显低于对照组(P<0.05)。治疗期间,两组患者均未见药品不良反应发生。结论:萘替芬酮康唑乳膏与伊曲康唑联用治疗复发性真菌性外耳道炎效果显著、安全性好。
Objective: To observe the efficacy and safety of itraconazole and naftifine conazole cream in the treatment of recurrent fungal otitis externa. Methods: 48 cases of recurrent fungal otitis externa were randomly divided into two groups. Twenty-four patients in the control group were given naftifine ketoconazole cream for qd for 2 weeks. The observation group of 24 cases based on the control group, plus itraconazole capsules 200 mg, po, qd, for 2 weeks. The short-term and long-term efficacy of the two groups were compared and safety was evaluated. Results: After two weeks of treatment, the total effective rate was 100.0% in the observation group, which was significantly better than 83.3% in the control group (P <0.05). Six months after the end of treatment, there was no recurrence in the observation group and the recurrence rate was 20.0% in the control group. The recurrence rate in the observation group was significantly lower than that in the control group (P <0.05). During the treatment, no adverse reactions occurred in both groups of patients. Conclusion: The combination of nifedipine and ketoconazole cream with itraconazole is effective and safe in treating recurrent fungal otitis externa.