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Ｎｍｉ基因编码一种可与Ｍｙｃ相互作用的蛋白质．在人红白血病细胞系ＴＦ－１细胞去细胞因子ＧＭ－ＣＳＦ后８ｈ，发现ＮｍｉＲＮＡ表达水平升高．利用ＰＣＲ方法从中扩增ＮｍｉｃＤＮＡ编码区，发现除正常大小的扩增片段外，还有一比公布核酸序列小约１００～２００ｂｐ的扩增片段．序列分析表明该片段为编码区第３３７～５０９位的碱基缺失，由ＧＴＴＣＣＡＴＴＧＣＧ１１个碱基取代，形成一个开放读码框架，编码２５４个氨基酸，比野生型Ｎｍｉ编码的３０７个氨基酸少５３个氨基酸．
The Nmi gene encodes a protein that interacts with Myc. In human erythroleukemia cell line TF-1 cells to cytokines GM-CSF 8h, NmiRNA expression was found to be elevated. Amplification of the NmicDNA coding region by PCR revealed that in addition to the normal amplified fragment, there was an amplified fragment about 100 ~ 200bp smaller than the published nucleic acid sequence. Sequence analysis showed that this fragment was a base deletion from the 337th to the 509th of the coding region and was substituted by 11 bases of GTTCCATTGCG to form an open reading frame encoding 254 amino acids 53 amino acids fewer than the 307 amino acids encoded by the wild type Nmi .