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甲型肝炎是我国广泛流行的急性传染病。我所与浙江省医科院合作,于1992年研制成功H2株甲肝减毒活疫苗,该疫苗是我国首创,国际领先。疫苗推广使用以来,全国甲肝发病率有了明显下降,取得了显著的社会效益及经济效益。疫苗病毒的毒力返祖可能性是活疫苗全面推广应用中极为关键的问题,本课题对此进行了深入研究,取得了富有理论及实用价值的结果。
Hepatitis A is a widely epidemic acute infectious disease in our country. In cooperation with Zhejiang Provincial Institute of Medical Sciences, I developed the H2 strain live attenuated attenuated hepatitis A vaccine in 1992. The vaccine is the first in our country and the leading in the world. Since the vaccine was introduced and used, the incidence of hepatitis A in the country has dropped significantly, and remarkable social and economic benefits have been achieved. The possibility of the virulence of the vaccine virus returning to the ancestor is an extremely crucial issue in the comprehensive popularization and application of the live vaccine. This topic has conducted in-depth research and achieved the results of rich theoretical and practical value.