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[目的]比较健脾益气中药联合化疗与单纯化疗治疗晚期大肠癌的临床疗效。[方法]47例晚期大肠癌患者随机分为治疗组(中药加化疗)和对照组(单纯化疗),观察临床疗效、生活质量、毒副反应及生存期。[结果]治疗组生活质量改善和毒副反应情况明显优于对照组(P<0.05);两组临床疗效及1、2、3年生存率和中位生存期比较差异无统计学意义(P>0.05)。[结论]健脾益气中药联合化疗可改善晚期大肠癌患者的生活质量、减少化疗药物的毒副反应。
[Objective] To compare the clinical curative effect of Jianpiyiqi combined with chemotherapy and chemotherapy alone in the treatment of advanced colorectal cancer. [Method] Forty-seven patients with advanced colorectal cancer were randomly divided into treatment group (traditional Chinese medicine plus chemotherapy) and control group (chemotherapy alone), and clinical efficacy, quality of life, toxicity and survival were observed. [Results] The improvement of quality of life and adverse reactions in the treatment group were significantly better than those in the control group (P <0.05). There was no significant difference between the two groups in the clinical curative effect and the 1-, 2-, 3- year survival rates and the median survival time (P > 0.05). [Conclusion] The combination of Chinese herbs of strengthening spleen and qi and chemotherapy can improve the quality of life of patients with advanced colorectal cancer and reduce the toxic and side effects of chemotherapy drugs.