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DNA瞬态损伤(DNA自由基)引起DNA碱基对断裂和双螺旋结构下沉,导致基因失稳,可能是构成癌变的最早事件。基因失稳是癌的共同特征标志之一,而DNA修复可通过维持基因完整性来降低癌的发生。修复DNA的能力低下也是癌的共同特征标志之一。近年新发现了一种独特的修复机制,称为快速修复,专一地修复DNA瞬态损伤,只需几个微秒就能完成,比已知的酶性修复快十亿倍,修复速率常数达到109L.mol-1.s-1。还发现凡是具有快速修复能力的植物多酚类几乎都能不同程度地削弱癌的特征标志,包括使癌细胞形态正常化、抑制癌细胞增殖、促进癌细胞分化或凋亡、降低端粒酶活性、减少植瘤率、阻止细胞迁移和扩散、抑制血管生成、延长存活时间、降低患癌风险等。
Transient damage to DNA (DNA free radicals) causes DNA base-pair breaks and double-helical structures to sink, leading to genetic instability that may be the earliest event that constitutes cancer. Genetic instability is one of the common hallmarks of cancer, and DNA repair reduces cancer by maintaining genetic integrity. The ability to repair DNA is also one of the hallmarks of cancer. In recent years, a unique repair mechanism was discovered, called rapid repair, specifically to repair DNA transient damage in just a few microseconds, a billion times faster than known enzymatic repair, repair rate constant Reached 109L.mol-1.s-1. It was also found that almost all of the plant polyphenols with rapid repair ability can weaken the signs of cancer to some extent, including normalizing the morphology of cancer cells, inhibiting the proliferation of cancer cells, promoting the differentiation or apoptosis of cancer cells, and reducing the telomerase activity , Reduce the rate of tumor, prevent cell migration and proliferation, inhibit angiogenesis, prolong survival time and reduce the risk of cancer.