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Objective To investigate and analyze the effect ofpravastatin on vascular endothelial function in unstable angina patients.Methods 100 patients with unstable angina received in our hospital from Mar 2011 to Mar 2013 were divided into observation group and control group according to a random number table, with 50 cases in each group.The patients in control group were given conventional isosorbidedinitrate, enteric-coated aspirin tablets, β-blockers, nitroglycerin and heparin for treatment; the observation group was given pravastatin tablets on the base of control group.The total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), endothelin (ET), nitric oxide (NO), and malondialdehyde (MDA) levels in the two groups of patients before treatment and after six weeks treatment were compared and analyzed.Results Total cholesterol, triglycerides and low-density lipoprotein cholesterol levels in observation group after treatment were significantly lower than the control group, the differences were statistically significant (t =4.851, 6.325, 4.851, P <0.05), while high-density lipoprotein cholesterol levels were significantly higher than control group, there was statistically significant difference (t=4.743, P <0.05); ET and MDA levels in observation group after treatment was significantly lower than the control group, the differences were statistically significant (t=3.462, 2.219, P<0.05), and the nitric oxide levels were significantly higher the control group, the differences were statistically significant (t=2.871, P<0.05).Conclusion Pravastatin combined conventional therapy for unstable angina pectoris can effectively improve endothelial function, lower blood lipids, stabilize blood pressure, and worthy of promotion.