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目的探讨冠心病(CHD)患者血清中血管内皮细胞生长因子(VEGF)水平与幽门螺杆菌(H.pylori)抗体之间的相关性。方法选取2013年2月至2015年2月医院接受治疗的冠心病患者共60例,以及60例体检没有冠心病的健康者,对患者的VEGF和Hp-IgG进行检测,观察两组的测定结果。结果观察组患者Hp-IgG阳性的例数明显高于对照组,Hp-IgG阴性的例数率明显低于对照组,差异有统计学意义(χ2=15.873,P<0.001);观察组患者Hp-IgG阳性血清VEGF(t=20.37,P<0.05)和Hp-IgG阴性血清VEGF水平明显低于对照组(t=9.02,P<0.05),对比差异有统计学意义。结论 CHD患者血清中VEGF水平与H.pylori感染情况有很大关系,对VEGF和Hp-IgG实施检测,对冠心病疾病的发展、病变、诊断、预后都有非常重要的意义。
Objective To investigate the correlation between the level of serum vascular endothelial growth factor (VEGF) and H. pylori antibody in patients with coronary heart disease (CHD). Methods From February 2013 to February 2015, 60 patients with coronary heart disease and 60 healthy people without physical examination were enrolled in this study. VEGF and Hp-IgG levels in patients were measured. The results of two groups were observed . Results The number of Hp-IgG positive cases in the observation group was significantly higher than that in the control group, and the incidence of Hp-IgG negative cases was significantly lower than that in the control group (χ2 = 15.873, P <0.001). Hp -IgG positive serum VEGF (t = 20.37, P <0.05) and Hp-IgG negative serum VEGF levels were significantly lower than the control group (t = 9.02, P <0.05), the difference was statistically significant. Conclusion Serum levels of VEGF in CHD patients are closely related to H. pylori infection. Detection of VEGF and Hp-IgG in CHD patients is of great significance for the development, diagnosis, prognosis of coronary heart disease.