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吡噻硫酮(Oltipraz)是一种新的抗曼氏和埃及血吸虫病的有效药物。对志愿者的试验发现,在进食时服药,比空腹服药的血浆浓度大4.5倍。本研究旨在测定进食时服药是否会增加吡噻硫酮的生物利用度,从而提高其抗血吸虫的效果。观察对象为苏丹男性曼氏血吸虫病人,均无腹水或其他晚期症状。25例病人分成两组,第1组14例,年龄7～52岁,第2组11例,年龄10～42岁,每例均用改良加藤法作粪便虫卵计数,两组病人的体重和
Oltipraz is a new drug that is effective against Mann and Egyptian schistosomiasis. A trial of volunteers found that taking the drug at mealtime was 4.5 times greater than the fasting plasma dose. The aim of this study was to determine if taking the drug during feeding would increase the bioavailability of oltipraz and improve its efficacy against schistosomiasis. Subjects were observed in Sudan man’s Schistosoma mansoni, no ascites or other advanced symptoms. 25 patients were divided into two groups, the first group of 14 cases, aged 7 to 52 years old, the second group of 11 cases, aged 10 to 42 years old, each case were modified Kato method for egg count stool eggs, two groups of patients with body weight and