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The Voronoi cell finite element method (VCFEM) is adopted to overcome the limitations of the classic displacement based finite element method in the numerical simulation of heterogeneous materials. The parametric variational principle and quadratic programming method are developed for elastic-plastic Voronoi finite element analysis of two-dimensional problems. Finite element formulations are derived and a standard quadratic programming model is deduced from the elastic-plastic equations. Influence of microscopic heterogeneities on the overall mechanical response of heterogeneous materials is studied in detail. The overall properties of heterogeneous materials depend mostly on the size, shape and distribution of the material phases of the microstructure. Numerical examples are presented to demonstrate the validity and effectiveness of the method developed.