ras癌基因产物P21在涎腺腺样囊性癌与腺淋巴瘤中的表达意义

• 作 者: 王素琴 董宝财 李映 芳田心
• 机 构: 昆明医学院口腔系,昆明医学院口腔系,昆明医学院口腔系,昆明医学院口腔系
• 出 处: 现代口腔医学杂志
• 发表日期: 2004年期
• 关键词: 腺淋巴瘤 涎腺腺样囊性癌 P21 ras癌基因 阳性病例 过氧化酶 活检标本 实质性肿瘤 临床病理诊断 原癌基因

目的　通过对涎腺腺样囊性癌与腺淋巴瘤中的ras 癌基因产物P21 蛋白的表达研究, 探讨ras 癌基因与涎腺恶性肿瘤的关系。方法　采用免疫组化S- P 法对25 例腺样囊性癌与22 例腺淋巴瘤中ras- P21 蛋白表达状况行了检测。结果　腺样囊性癌阳性表达率为92 % (23/25) , 腺淋巴瘤阳性率为22 .7 % (5/22) 。经χ2 检验二者阳性率差异有非常显著意义( P< 0 .005) 。结论　腺样囊性癌的发病与ras 癌基因的激活有密切关系。

Objective To investigate the relationship between ras oncogene and salivary gland malignancy by studying the expression of ras oncogene P21 protein in salivary adenoid cystic carcinoma and adenolymphoma. Methods The expression of ras-P21 in 25 cases of adenoid cystic carcinoma and 22 cases of adenolymphoma was detected by immunohistochemical S-P method. Results The positive rate of adenoid cystic carcinoma was 92% (23/25). The positive rate of adenolymphoma was 22.7% (5/22). There was a significant difference in the positive rate between the two groups (χ2 test, P <0 .005). Conclusion The incidence of adenoid cystic carcinoma is closely related to the activation of ras oncogene.