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应用放射免疫法测定137例各型肝病患者空腹血清胃泌素含量。结果表明急性肝炎、慢性肝炎及肝硬化无静脉曲张组血清胃泌素含量基本正常，与对照无明显差异。肝硬化门脉高压伴食道胃底静脉曲张组胃泌素含量显著增高，是无静脉曲张组的1．55倍，两组差异显著（P＜0．05）。肝硬化静脉曲张组与正常对照相比（P＜0．01）。提示该组有高胃泌素血症。高胃泌素血症与静脉曲张程度及胃粘膜病变引起的上消化道出血密切相关，血清胃泌素含量愈高，并发上消化道出血机会愈多。为此，对肝硬化门脉高压合并静脉曲张及胃粘膜病变者血清胃泌素测定对预测消化道出血有一定的临床价值。
Fasting serum gastrin levels in 137 patients with various liver diseases were determined by radioimmunoassay. The results showed that acute gastritis, chronic hepatitis and cirrhosis without varicose veins serum gas content was normal, no significant difference with the control. Gastrin levels in cirrhotic patients with portal hypertension and esophageal varices were significantly higher than those in patients without varicose veins (1.55-fold, P <0.05). Cirrhosis varicose vein group compared with the normal control (P <0.01). Suggest that the group had hypergastrinemia. Hypergastrinmia and varicose veins and gastric mucosal lesions caused by upper gastrointestinal bleeding are closely related to the higher the serum gastrin levels, the more chances of upper gastrointestinal bleeding. To this end, cirrhosis and portal hypertension with varicose veins and gastric mucosal lesions serum gastrin determination of gastrointestinal bleeding have some clinical value.