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目的观察替米沙坦对肾素、血管紧张素Ⅱ、醛固酮的影响和降压疗效。方法选择100例轻中度高血压患者,给予替米沙坦80mg,1次/d,共治疗8周,观察治疗前后血压、心率、肾素、血管紧张素Ⅱ、醛固酮等指标的变化。结果治疗后收缩压和舒张压较治疗前均明显下降(P<0.01),治疗后血管紧张素Ⅱ含量明显增高(P<0.01),而醛固酮含量则较治疗前降低(P<0.01),治疗后肾素活性有明显增高(P<0.05)。结论替米沙坦降压安全有效,且耐受性好,不良反应轻微,是一种比较理想的新型降压药物。
Objective To observe the effect of telmisartan on renin, angiotensin Ⅱ, aldosterone and antihypertensive effect. Methods 100 patients with mild to moderate hypertension were given telmisartan 80 mg once a day for 8 weeks. The changes of blood pressure, heart rate, renin, angiotensin Ⅱ and aldosterone were observed before and after treatment. Results After treatment, the systolic and diastolic blood pressures were significantly lower than those before treatment (P <0.01). After treatment, the content of angiotensin Ⅱ was significantly increased (P <0.01), while the aldosterone level was decreased (P <0.01) After renin activity was significantly increased (P <0.05). Conclusion Telmisartan is safe and effective in lowering blood pressure and is well tolerated with mild adverse reactions. It is an ideal new antihypertensive drug.