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目的：实验利用裸鼠背部皮瓣进行研究，以确定术中即刻扩张术是否优于单纯皮下分离。方法：将９０只裸鼠分为三组，并制成背部皮瓣。单纯分离组仅作皮下分离，１次扩张组和２次扩张组用Ｆｏｌｅｙ氏导管，以６ｍｌ的扩张量，分别扩张１次和２次，每次扩张时间３ｍｉｎ。利用张力测定仪、多普勒和计算机观察分析皮瓣的活力、微循环血流量，以及张力和长度的变化。结果：三组之间，术后皮瓣的微循环血流量和活力均无明显差异，而２次扩张组皮瓣张力的降低和长度的增加均比单纯分离组和１次扩张组明显。结论：２次扩张的方法比单纯皮下分离或１次扩张的方法优越。
OBJECTIVE: Experiments were performed using a nude back flap to determine if intraoperative immediate dilatation is superior to simple subcutaneous. Methods: 90 nude mice were divided into three groups and made into back skin flap. The isolated group was only subcutaneously. The primary and secondary expansion groups were treated with Foley ’s catheter and the volume of 6ml was used to dilate one and two times respectively, each dilation time was 3min. Tensiometer, Doppler and computer were used to analyze the changes of flap vitality, microcirculation blood flow, and tension and length. Results: There was no significant difference in the microcirculation blood flow and vitality between the three groups and the postoperative flap, while the decrease of the flap tension and the length of the flap in the second expansion group were more obvious than the simple separation group and the first expansion group. Conclusion: The method of 2 dilation is superior to that of simple subcutaneous or 1 dilation.