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目的探究妊娠期高血压患者血凝指标变化的临床意义,为临床提供参考。方法将正常体检和分娩的孕产妇350例按有无合并高血压分为妊娠期高血压组(实验组)75例和正常妊娠晚期孕妇组(对照组)275例,对两组的凝血指标进行检测。结果实验组平均血小板体积(mean platelet volume,MPV)、纤维蛋白原水平(fibrinogen,FIB)、D-二聚体水平高于对照组(t=13.182、10.497、23.880,P=0.000),实验组血小板计数(platelet count,PC)低于对照组(t=2.140,P=0.033),凝血酶原时间(prothrombin time,PT)、部分凝血活酶时间(apartial thromboplastin time,APTT)也少于对照组(t=9.572,P=0.000;t=3.109,P=0.002);轻度子痫前期PC高于重度子痫前期(P<0.05),FIB、D-二聚体水平低于重度子痫前期(P<0.05或0.01);早发型子痫前期的PT少于晚发型子痫前期(P<0.05),FIB、D-二聚体水平高于对照组(P<0.01)。结论妊娠期高血压疾病有明显的高凝现象,且凝血程度与病情严重度有关,有重要临床参考价值。
Objective To investigate the clinical significance of changes of hemagglutination index in patients with gestational hypertension to provide reference for clinical practice. Methods 350 cases of normal physical examination and delivery of pregnant women with or without hypertension were divided into 75 cases of hypertensive pregnancy group (experimental group) and 275 cases of normal pregnant women group (control group), the two groups of coagulation parameters Detection. Results The mean platelet volume (MPV), fibrinogen (FIB) and D-dimer in the experimental group were significantly higher than those in the control group (t = 13.182,10.497,23.880, P = 0.000) The platelet count (PC) was lower than that of the control group (t = 2.140, P = 0.033). Prothrombin time (PT) and partial thromboplastin time (APTT) (t = 9.572, P = 0.000; t = 3.109, P = 0.002). The PC of mild preeclampsia was higher than that of severe preeclampsia (P <0.05), and the levels of FIB and D-dimer were lower than those of severe preeclampsia (P <0.05 or 0.01). The PT of early onset preeclampsia was less than that of late onset preeclampsia (P <0.05), and the levels of FIB and D-dimer were higher than those of the control group (P <0.01). Conclusion Hypertensive disorders in pregnancy have obvious hypercoagulability, and the degree of coagulation is related to the severity of the disease, which has important clinical reference value.