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在前两文[1][2]中,我们报道了用管道法合成了三个冠醚。为了进一步扩大这种方法的应用范围,在本文中除了对前述三个冠醚(Ⅰ、Ⅱ、Ⅴ)改用不同的纯化方法仍能重复外,还首次用新方法合成了冠醚Ⅲ和Ⅳ以及未见文献报道的新冠醚Ⅵ。以上均属酰氯与甘醇缩合而成的内酯型冠醚。对于另一种类型的冠醚即需用金属离子起模板作用来合成的冠醚Ⅶ和Ⅷ能否采用管道反应呢?我们的实验结果是成功的,但产率有待于进一步提高。新方法在缩短反应时间、节省溶剂用量以及简化纯化操作步骤等方面,都取得较好的结果,产品经分析鉴定与预期结构相符。其数据见表二所示。
In the first two papers [1] [2], we report the synthesis of three crown ethers by pipework. In order to further expand the scope of application of this method, in addition to the above three crown ethers (Ⅰ, Ⅱ, Ⅴ) to use different purification methods can still be repeated, but also for the first time using new methods crown ethers Ⅲ and Ⅳ As well as the new crown ether Ⅵ not reported in the literature. These are acid chloride and glycol condensation lactone crown ether. For another type of crown ether that requires the use of metal ions as a template to synthesize crown ether Ⅶ and Ⅷ pipe reactions can be used? Our experimental results are successful, but the yield needs to be further improved. The new method has achieved good results in terms of shortening the reaction time, saving the amount of solvent and simplifying the steps of purification, and the product is identified by analysis in accordance with the expected structure. The data shown in Table II.