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东南亚及南美洲多种抗性的恶性疟原虫的扩散及非洲出现抗氯喹恶性疟原虫,显示迫切需要控制这些原虫的替代药物。一种4-喹啉甲醇类药物甲氟喹是唯一的正处于发展阶段的新药。经动物模型及临床研究证明,本药是一种对抗氯喹虫株及抗乙胺嘧啶虫株红内期无性体的高效杀灭剂,但不是一种病因性预防药。临床前的毒理学畸胎学、致癌力的研究无任何使用该药的重要禁忌指征。经过在非洲、南北美洲、东南亚及欧洲的深入临床试用,显示本药副作用小,安全、有效,特别是对抗氯喹恶性疟有效。为了防止这个有希望的新药在地方性流行区出现抗性,在引进此药前应作好合理和审慎的安排,其预防办法包括与其他药物合用(甲氟喹与乙胺嘧啶-周效磺胺合用已在研究中),与伯喹作为配子体杀灭药合用以防止传播,以及仅可用于治疗。只有在特别危险的情况下才用于预防服药。
The spread of multiple resistant Plasmodium falciparums in Southeast and South America and the emergence of anti-chloroquine-resistant Plasmodium falciparum in Africa have shown the urgent need for alternative medicines that control these protozoa. A 4-quinoline carbinol mefloquine is the only new drug currently under development. Animal models and clinical studies have shown that the drug is a high resistance to chloroquine insects and anti-pyrimethamine intra-red stage asexuals efficient killing agent, but not a causal agent. Preclinical toxicology Teratology, carcinogenicity of the study without any significant indications taboo use of the drug. After in-depth clinical trials in Africa, North and South America, Southeast Asia and Europe, the drug side effects are small, safe and effective, especially against chloroquine falciparum malaria. In order to prevent the emergence of a promising new drug in endemic areas, reasonable and prudent arrangements should be made prior to the introduction of the drug, and its prophylaxis includes combination with other drugs (mefloquine and pyrimethamine-psoraleamide The co-use has been studied), combined with primaquine as a gametophyte killing agent to prevent transmission, and is only available for treatment. Use it only in especially dangerous situations to prevent medication.