诱导型一氧化氮合酶抑制剂的特性:临床治疗展望(英文)

• 作 者: 刘昭前 Stephen M WILDHIRT 周宏灏
• 机 构: 湖南医科大学基础与临床药理学研究所,Department of Cardiac Surgery, Ludwig-Maximilians University, Munich 81377, German
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1999年11期
• 关键词: 一氧化氮合酶 sustained rejection pathogenesis allograft modulator arginine quantities

Nitric oxide (NO ) is a ubiquitous, naturallyoccurring molecule found in a variety of cell types andorgan systems. It is a double-edged sword, beneficialas a messenger or modulator and for immunology self-defense, but potentially toxic. The formation andsignal function of nitric oxide are mainly modulated bynitric-oxide synthase (NOS ). Up to the present, anumber of diseases, including circulatory shock,atherosclerosis, cardiac allograft rejection, chronicinflammation, cardiac infarction, cancer and so on,have been demonstrated that their pathogenesis may beinvolved in the sustained production of large quantities

Nitric oxide (NO) is a ubiquitous, naturallyoccurring molecule found in a variety of cell types andorgan systems. It is a double-edged sword, beneficialas a messenger or modulator and for immunology self-defense, but potentially toxic. The formation and signaling function of Up to the present, anumber of diseases, including circulatory shock, atherosclerosis, cardiac allograft rejection, chronic inflammation, cardiac death, cancer and so on, have been demonstrated that their pathogenesis may beinvolved in the sustained production of large quantities