血管内皮对狗离体冠状动脉β肾上腺素受体激动剂反应性的影响(英文)

• 作 者: 唐子略 邬文建 熊小明
• 机 构: 湖南医科大学药理教研室,湖南医科大学药理教研室,湖南医科大学药理教研室 长沙 410078 中国,长沙 410078 中国,长沙 410078 中国
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1995年04期
• 关键词: β肾上腺素受体 异丙肾上腺素 冠状血管 舒张作用 endothelium 妥拉 合成酶抑制剂 prostaglandin 生理记录仪 ceptor

目的:研究内皮细胞对离体冠状动脉β肾上腺素受体激动剂反应性的影响.方法:狗冠状动脉环离体实验,生理记录仪记录血管张力.结果:去甲肾上腺素(NE)和异丙肾上腺素(Iso)引起离体狗冠状动脉剂量依赖性舒张反应,酚妥拉明加强NE的作用.血管去内皮后,对NE和Iso的反应减弱,一氧化氮(NO)合成酶抑制剂N~ω-硝基左旋精氨酸甲酯亦可减弱NE和Iso的作用.结论:β肾上腺素受体激动剂对狗冠状动脉舒张作用部分依赖于内皮.此作用由NO介导.

OBJECTIVE: To study the effect of endothelial cells on the reactivity of isolated β-adrenergic agonists in coronary artery.Methods: The coronary artery rings were isolated from dogs and the vascular tone was recorded with a physiological recorder.Results: The levels of norepinephrine Propranolol (Iso) induced a dose-dependent vasodilatory response in isolated dog coronary artery, and phentolamine enhanced the action of NE.When the endothelium was decellularized, the response to NE and Iso was weakened, nitric oxide synthase inhibitor N ~ ω-nitro-L-arginine methyl ester also attenuated the effects of NE and Iso.Conclusion: β-adrenoceptor agonists partially dependent on the endothelium of the coronary arteries, which is mediated by NO.