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目的研究在多囊卵巢综合征合并不孕中应用二甲双胍+克罗米芬的临床治疗效果。方法 116例多囊卵巢综合征合并不孕患者作为研究对象,随机分为对照组(实施克罗米芬治疗)及观察组(实施二甲双胍+克罗米芬治疗),各58例。比较两组患者的临床治疗效果。结果观察组体质量指数(BMI)、空腹胰岛素(FINS)、促黄体生成素(LH)均低于对照组,差异具有统计学意义(t=8.4853、8.6197、9.7838,P<0.05)。观察组患者的排卵率74.14%及妊娠率36.21%均高于对照组25.86%、12.07%,差异具有统计学意义(χ2=27.0345、9.2273,P<0.05)。结论对多囊卵巢综合征合并不孕临床患者而言,实施二甲双胍+克罗米芬的治疗,能够提升患者对胰岛素相关敏感性,且降低了激素水平等,对排卵率和妊娠率有提高作用。
Objective To study the clinical effect of metformin + clomiphene in patients with polycystic ovary syndrome complicated with infertility. Methods A total of 116 patients with PCOS complicated by infertility were randomly divided into control group (clomiphene citrate group) and observation group (metformin + clomiphene citrate group), 58 cases in each group. The clinical effects of the two groups were compared. Results Body mass index (BMI), fasting insulin (FINS) and luteinizing hormone (LH) in the observation group were lower than those in the control group (t = 8.4853,8.6197,9.7838, P <0.05). The ovulation rate and pregnancy rate in observation group were 74.14% and 36.21% respectively, which were significantly higher than those in control group (25.86% and 12.07%, respectively) (χ2 = 27.0345,9.2273, P <0.05). Conclusions For clinical patients with polycystic ovary syndrome complicated by infertility, metformin + clomiphene citrate treatment can improve insulin sensitivity and reduce hormone levels, which may have an effect on ovulation rate and pregnancy rate.