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采用沙土鼠双侧颈总动脉夹闭１０ｍｉｎ或２０ｍｉｎ后再灌７ｄ或１ｄ，造成脑缺血再灌损伤模型，观察阿司匹林铜对沙土鼠脑组织钙、水含量的影响，及对海马ＣＡ１区神经元迟发性损伤的保护作用．结果显示：阿司匹林铜（７．５ｍｇ／ｋｇ）即能减轻脑组织钙累积，剂量１５ｍｇ／ｋｇ能增加脑缺血后海马ＣＡＩ区的神经元密度．提示阿司匹林铜对缺血再灌脑组织损伤有一定的保护作用．
The occlusion of gerbil bilateral common carotid artery 10min or 20min after reperfusion 7d or 1d, resulting in cerebral ischemia-reperfusion injury model to observe the effect of aspirin on brain calcium and water content in gerbils, and on the hippocampal CA1 nerve Delayed injury of the protective effect. The results showed that aspirin copper (7.5 mg / kg) could reduce the accumulation of calcium in brain tissue. A dose of 15 mg / kg could increase neuronal density in CA1 hippocampus after cerebral ischemia. Suggesting that aspirin copper has a certain protective effect on tissue damage caused by ischemia-reperfusion.