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肿瘤和血凝异常有关,癌瘤患者血凝变化的问题是个复杂的问题,它可能包括栓塞和出血两方面。凝血因子和肿瘤组织的糖蛋白的性质已成为人们深入研究的主题。人癌的细胞膜糖蛋白和糖基转移酶含量升高,特别是位于膜糖蛋白侧链末端的糖——唾液酸可能影响肿瘤细胞的生长。已有报告指出急性期的糖蛋白反应物尤其是含有丰富唾液酸的糖蛋白反应物可作为肿瘤的标志。改变血小板表面的唾液酸和涎基转移酶(Sialytransferase,简称STA)的含量可以影响血小板的功能,改变凝血因子的唾液酸含量也可以影响血凝。Warren报告血小板和肿瘤细胞相互作用形成血小板——肿瘤栓子,Gasic等证实了各种人、大鼠和小
Tumors are related to abnormal blood coagulation. The problem of blood coagulation changes in cancer patients is a complex issue. It may include both embolism and hemorrhage. The properties of coagulation factors and tumor tissue glycoproteins have become the subject of intense research. Human cancers have elevated levels of cell membrane glycoproteins and glycosyltransferases, particularly sugars located at the end of the membrane glycoprotein side chain, sialic acid, which may affect tumor cell growth. It has been reported that acute phase glycoprotein reactants, especially sialic acid-rich glycoprotein reactants, may serve as tumor markers. Changes in platelet surface sialic acid and thiol transferase (Sialytransferase, referred to as STA) content can affect platelet function, changing the sialic acid content of clotting factors can also affect blood clotting. Warren reports that platelets and tumor cells interact to form platelets - tumor emboli, and Gasic et al. have confirmed various human, rat, and small