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目的探讨孕期注射乙肝免疫球蛋白的孕妇分娩的婴儿对乙肝疫苗免疫应答情况。方法以HBsAg阳性孕妇及其新生儿为研究对象,孕期母亲注射乙肝免疫球蛋白的300例新生儿为实验组,未使用者80例为对照组,比较两组新生儿出生时及联合免疫后7个月anti-HBs产生情况。结果实验组与对照组婴儿出生时anti-HBs阳性率分别为10.3%(31/300)和1.25%(1/80),差异有统计学意义;7个月龄实验组anti-HBs产生率为96.1%(124/129),对照组anti-HBs产生率95.3%(41/43),差异无统计学意义;出生时anti-HBs阳性的新生儿25例,7个月龄均产生anti-HBs,出生时anti-HBs阴性或弱阳性的147例婴儿中有7例婴儿anti-HBs仍为阴性或弱阳性,差异有统计学意义。结论孕期使用乙肝免疫球蛋白可提高新生儿出生时anti-HBs产生率,但对7个月anti-HBs产生率无影响。
Objective To investigate the immune response to hepatitis B vaccine in infants born to pregnant women who were injected with hepatitis B immunoglobulin during pregnancy. Methods HBsAg positive pregnant women and their newborns as the research object, pregnant mothers injected hepatitis B immunoglobulin in 300 newborns as experimental group, 80 cases of non-users as the control group, compared two groups of newborns at birth and after co-immunization 7 Month anti-HBs production. Results The positive rates of anti-HBs in the experimental group and the control group were 10.3% (31/300) and 1.25% (1/80) at birth, respectively, and the difference was statistically significant. The incidence of anti-HBs in the 7-month- 96.1% (124/129) in the control group, and 95.3% (41/43) in the control group. There were no significant differences between the two groups in anti-HBs antigens Seven of the 147 infants with anti-HBs negative or weak positive at birth were still negative or weakly positive, the difference was statistically significant. Conclusion The use of hepatitis B immunoglobulin during pregnancy can increase the neonatal anti-HBs production rate, but had no effect on the anti-HBs production rate at 7 months.