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目的：了解安氟醚对缺血性预处理心肌保护作用的影响。方法：ＳＤ大鼠离体心脏采用Ｌａｎ－ｇｅｎｄｏｒｆ装置灌流。３２只大鼠随机分为对照组、安氟醚组（Ｅｎｆ组）、缺血预处理组（ＩＰ组）和安氟醚加缺血预处理组（Ｅｎｆ＋ＩＰ组）。连续监测ＬＶＥＤＰ、ＬＶＳＰ、ＤＰ、±ｄｐ／ｄｔ、ＨＲ和缺血期挛缩情况，测冠脉流量和冠流液中ＬＤＨ、蛋白含量。结果：ＩＰ和Ｅｎｆ＋ＩＰ两组心肌挛缩压力显著降低（Ｐ＜０．０１），安氟醚使挛缩时间明显延迟（Ｐ＜０．０１）。复灌期、实验各组心肌舒缩功能和冠脉流量的恢复、ＬＤＨ和蛋白含量的下降均显著优于对照组（Ｐ＜０．０５，Ｐ＜０．０１），但Ｅｎｆ组的作用不及ＩＰ和Ｅｎｆ＋ＩＰ组（Ｐ＜０．０５），ＩＰ和Ｅｎｆ＋ＩＰ两组间心功能的恢复无差异，但Ｅｎｆ＋ＩＰ组冠脉流量、ＬＤＨ和蛋白含量的恢复明显好于ＩＰ组（Ｐ＜０．０５）。结论：安氟醚、ＩＰ都有明显的心肌保护作用。安氟醚对复灌期ＩＰ心功能的恢复无增强作用，但能增强ＩＰ对心肌细胞的保护作用。
Objective: To investigate the effect of enflurane on ischemic preconditioning myocardial protection. Methods: Sprague-Dawley rats were perfused with Lan-gendorf apparatus. 32 rats were randomly divided into control group, Enf group (Enf group), ischemic preconditioning group (IP group) and enflurane plus ischemic preconditioning group (Enf + IP group). Continuous monitoring of LVEDP, LVSP, DP, ± dp / dt, HR and ischemic contracture, coronary flow and coronary fluid LDH, protein content. Results: Myocardial contracture pressure was significantly lower in both IP and Enf + IP groups (P <0.01), and enflurane significantly delayed the contracture time (P <0.01). During the reperfusion period, the recovery of myocardial systolic and diastolic function and coronary flow, the decrease of LDH and protein content in the experimental groups were significantly better than those in the control group (P <0.05, P <0.01), but not in the Enf group IP and Enf + IP groups (P <0.05). There was no difference in the recovery of cardiac function between IP and Enf + IP groups, but the recovery of coronary flow, LDH and protein content in Enf + IP group was significantly better than that in IP group (P <0.05) . Conclusion: Both enflurane and IP have obvious myocardial protective effect. Enflurane did not enhance the recovery of IP heart function during reperfusion, but enhanced the protective effect of IP on cardiomyocytes.