论文部分内容阅读
在清醒正常血压大鼠、免以及肾型高血压大鼠,比较了m-nif、nif及nitr的降压强度,和降压的时间动态过程,三药的降压作用与对照组及自身前后对比,统计学上均非常显著。m-nif与nitr降压持续时间较nif长。从清醒正常血压大鼠降压的量效关系比较,m-nif、nif和nitr的ED_(50)分别为33.7±3.4,45.6±3.6和51.2±4.1 mg/kg(即90±9,132±10,142±11μmol/kg)。按克分子量计算对比m-nif的降压强度最大,nitr最弱。但三药对正常血压及肾型高血压动物的降压作用,按组间对比,无统计学差异。
In normotensive rats and in renal hypertensive rats, the antihypertensive effects of m-nif, nif and nitr and the time-course of antihypertensive treatment were compared. The antihypertensive effects of three drugs were compared with the control group and before and after In contrast, the statistics are very significant. The duration of m-nif and nitr depressurization is longer than nif. The dose-response relationship between m-nif, nif and nitr was 33.7 ± 3.4, 45.6 ± 3.6 and 51.2 ± 4.1 mg / kg (ie, 90 ± 9, 132 ± 10, 142 ± 11 μmol / kg). In terms of molecular weight comparison, m-nif has the highest buck strength and the weaker nitr. However, the three drugs on normotensive and antihypertensive effects of antihypertensive animals, according to the comparison between groups, no significant difference.