论文部分内容阅读
卷曲霉素又名卷须霉素,与国外报导的缠霉素(Capreomycin)为相同的抗结核抗菌素。化学结构是一种环状多肽。临床应用它的二硫酸盐,系白色或微黄色粉末,易溶于水,难溶于各种有机溶剂。其水溶液在 pH 4—8比较稳定。[作用方式和抗菌作用]卷曲霉素的抗菌作用主要在于阻碍其细胞的蛋白合成。对结核杆菌的抑制作用与乙胺丁醇、乙硫异烟胺相仿,低于链霉素、卡那霉素而略胜于紫霉素。卷曲霉素与异烟肼、对氨柳酸、链霉素、乙胺丁醇、乙硫异烟胺、环丝氨酸以及利福平
Capreomycin, also known as curvirin, is the same anti-tuberculin antibiotic as reported abroad for Capreomycin. The chemical structure is a cyclic polypeptide. Its clinical application of its disulfate, Department of white or yellowish powder, soluble in water, insoluble in various organic solvents. Its aqueous solution is relatively stable at pH 4-8. [Mode of action and antibacterial effect] Captamycin antibacterial effect mainly hindered the protein synthesis of their cells. Mycobacterium tuberculosis inhibition and ethambutol, ethionamide is similar to less than streptomycin, kanamycin and slightly better than the purple penicillin. Capreomycin with isoniazid, salicylic acid, streptomycin, ethambutol, ethionamide, cycloserine and rifampicin