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近20多年来,由于放射性同位素标记的强心甙的合成,对强心甙代谢的研究有很大进展。目前临床研究常用标记的强心甙有C~(14)—Digitoxin(洋地黄毒甙,简称D. T.)和H~3—Digoxin(地高辛,D. G)。前者用以代表作用久的强心甙类,首先被用于研究强心甙在人体的代谢。后者用以代表作用暂短的强心甙类。一、洋地黄毒甙的代谢以C~(14)—D. T. 研究证明:无论人或动物口服C~(14)—D. T. 后,能完全从胃肠道吸收,一般在服药后
In recent 20 years, due to the synthesis of radioisotope-labeled cardiac glycosides, research on the metabolism of cardiac glycosides has made great progress. Cardiac glycosides commonly used in clinical studies are C ~ (14) -Digitoxin (Digoxin, D.T.) and H ~ 3-Digoxin (Digoxin, D.G.). The former is used to represent long-acting cardiac glycosides, first used to study cardiac glycosides in the body’s metabolism. The latter is used to represent short acting cardiac glycosides. First, the metabolism of digitoxin to C ~ (14) -D. T. Studies have shown that: either human or animal oral C ~ (14) -D.T, can completely absorbed from the gastrointestinal tract, usually after taking the drug