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经腹绒毛膜绒毛采样(TA-CVS)技术,1986年首先由Smidt-Jensen等报告在孕早期施行。同年,Nicolaides等又报告在孕中期使用。至1989年,用TA-CVS法已超过所有绒毛膜绒毛采样的10%。该法已认为比经宫颈绒毛膜绒毛采样(TC-CVS)简单实用,而且在防止子宫内细菌污染方面也更加安全。鉴于高龄孕妇是产前诊断最常见的适应症,TC-CVS技术胎儿丢失率又明显增高,作者为对高龄孕妇排除染色体异常,从1987年3月至1988年10月,利用TA-CVS技术,为高龄孕妇检查707例。孕妇年龄在36～49岁之间,平均37.9岁。孕龄依据末次月经与超声测量胎儿顶臀长度而确定。孕10.2～11.6周者121例(17.5%),12.0～14.6周者477例(67%),15.0～18.3周者109例(15.5%)。
Transvaginal chorionic villus sampling (TA-CVS) technology, first reported by Smidt-Jensen et al 1986 in early pregnancy. In the same year, Nicolaides et al reported again in the second trimester. By 1989, the TA-CVS method had surpassed 10% of all chorionic villus samples. The method has been considered simple and practical than the cervical chorionic villus sampling (TC-CVS), but also in the prevention of intrauterine bacterial contamination is also more secure. In view of the elderly prenatal diagnosis of the most common indications, TC-CVS fetal loss rate was significantly higher, the author of the elderly pregnant women to exclude chromosomal abnormalities, from March 1987 to October 1988, the use of TA-CVS technology, For the elderly pregnant women check 707 cases. Pregnant women aged 36 to 49 years old, with an average of 37.9 years old. Gestational age is based on the last menstrual and ultrasound measurements of the fetal top buttock length. There were 121 cases (17.5%) in 10.2 ~ 11.6 weeks of pregnancy, 477 cases (67%) in 12.0 ~ 14.6 weeks and 109 cases (15.0%) in 15.0 ~ 18.3 weeks.