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为探讨脑胶质瘤ＩＣＥ基因蛋白表达与肿瘤细胞凋亡及其与肿瘤恶性程度关系。用免疫组化和原位加尾技术（ＴＵＮＥＬ） 研究４０ 例脑胶质瘤，包括ⅠⅡ级１８ 例，ⅢⅣ级２２ 例。结果：低级组ＩＣＥ 表达阳性率８３－３ ％ ，阳性细胞数９５ ±１８，凋亡细胞数４２ ±１２ 。高级组ＩＣＥ 表达率４０－９ ％ ，阳性细胞数３７ ±１０ ，凋亡细胞数２１ ±９。两组间阳性表达率。免疫阳性细胞数，凋亡细胞数均有显著差异（ Ｐ＜ ０ ．０５） ，ＩＣＥ 表达与细胞凋亡呈正相关（ｒ＝ ０．５３１） 。结果说明：ＩＣＥ诱导肿瘤细胞凋亡，阻止肿瘤的侵袭生长。
To investigate the expression of ICE gene in glioma and its relationship with the degree of tumor malignancy. Forty gliomas were studied by immunohistochemistry and in situ TUNEL, including 18 cases of grade Ⅰ-Ⅱ and 22 cases of grade Ⅲ-Ⅳ. Results: The expression of ICE in the low grade group was 83.3%, the number of positive cells was 95 ± 18 and the number of apoptotic cells was 42 ± 12. High-grade group ICE expression rate of 40-9%, the number of positive cells 37 ± 10, the number of apoptotic cells 21 ± 9. Positive rate of expression between the two groups. The number of immunopositive cells and apoptotic cells were significantly different (P <0.05). The expression of ICE was positively correlated with apoptosis (r = 0.531). The results showed that ICE induced tumor cell apoptosis and prevented tumor invasion and growth.