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目的研究促酰化蛋白(acylation-stimulating protein,ASP)的功能受体C5L2基因的SNP位点C698T多态性与中山地区人群妊娠期糖尿病(GDM)的相关性。方法本研究采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对来自2012年2013年中山博爱医院共285例孕妇检测C5L2基因多态性,评估其与GDM的相关性。其中GDM组174例,血糖正常103例设为对照组。GDM组和对照组基因型分布运用logistic回归模型分析。GDM组相关表型运用多重回归模型分析。结果C5L2基因C698T杂合子基因型在GDM组和对照组的分布频率分别为0.6%和1.9%,差异不具有统计学意义(校正χ2=0.213,P=0.6>0.05)。基因型TT在GDM组和对照组均未发现。结论在中山地区人群中,C5L2基因C698T基因多态性与GDM的发生可能不具有相关性。
Objective To investigate the relationship between polymorphism of C698T polymorphism of C5L2, a functional receptor of acylation-stimulating protein (ASP), and gestational diabetes mellitus (GDM) in Zhongshan population. Methods A total of 285 pregnant women from Zhongshan Pok Oi Hospital from 2013 to 2013 were examined for the polymorphism of C5L2 gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in order to evaluate their association with GDM. One 174 cases of GDM group, 103 cases of normal blood glucose as the control group. GDM group and control group genotype distribution using logistic regression model analysis. GDM group related to the use of multiple regression model analysis. Results The genotype distribution of C5L2 C698T heterozygote was 0.6% and 1.9% respectively in GDM group and control group, with no significant difference (χ2 = 0.213, P = 0.6> 0.05). Genotype TT was not found in GDM group and control group. Conclusion In Zhongshan population, the polymorphism of C5L2 C698T gene may not be related to the occurrence of GDM.