论文部分内容阅读
目的 探讨允许性高碳酸血症通气法(PHV)在治疗新生儿呼吸窘迫综合征(NRDS)中的价值。方法 随机选择两组需机械通气治疗的NRDS病人,对照组(n=25)以传统通气方式治疗,PHV组(n=31)降低PIP、PEEP、MAP等通气条件,允许血气中PaCO_2超过正常值,在45～55mmHg之间,比较两组通气条件、通气过程中血气值及并发症、病死率。结果 两组在通气过程中,PaCO_2/FiO_2及PaCO_2无显著性差异(P均>0.05),而pH值、PaCO_2有显著性差异(P<0.05和P<0.01),同时PHV组上机时间显著减少(P<0.05),气漏发生率和病人死亡率均降低(0/12％和12.9％/24％)。结论 PHV法在治疗NRDS中较传统通气方式能降低并发症的发生率及病死率,具有推广价值。
Objective To investigate the value of permissive hypercapnic ventilation (PHV) in the treatment of neonatal respiratory distress syndrome (NRDS). Methods Two groups of NRDS patients who needed mechanical ventilation were selected at random. The control group (n = 25) was treated by traditional ventilation. The PHV group (n = 31) reduced the ventilation conditions such as PIP, PEEP and MAP, , Between 45 ~ 55mmHg, compared two groups of ventilation conditions, ventilation during the blood gas and complications, mortality. Results There was no significant difference in PaCO 2 / FiO 2 and PaCO 2 between PaCO 2 / FiO 2 and PaCO 2 in both groups (P> 0.05), but there was significant difference between pH and PaCO 2 (P <0.05 and P <0.01) (P <0.05), and the incidence of air leaks and patient mortality decreased (0/12% and 12.9% / 24%, respectively). Conclusion Compared with traditional ventilation, PHV can reduce the incidence of complication and mortality in NRDS, which has the promotion value.